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Alpsoy, L./ A. Asian/ E. Kotan/ G. Agar/ M. Anar 2011: Protective role of two lichens in human lymphocytes in vitro. - Fresenius Environmental Bulletin 20(7): 1661-1666. [RLL List # 224 / Rec.# 33203]
Keywords: Anti-oxidant enzymes/ Antigenotoxicity/ Lecanora muralis/ Rhizoplaca chrysoleuca/ aldehyde/ antagonism/ antioxidant/ concentration (composition)/ enzyme activity/ experimental study/ frequency analysis/ functional morphology/ genotoxicity/ lichen/ methanol/ species diversity
Abstract: In this study, the antagonistic effects of methanol extracts of Rhizoplaca chrysoleuca (RME) and Lecanora muralis (LME) were studied against effects of aflatoxin Bi (AFBi)-induced oxidative stress and genotoxicity in human lymphocytes in vitro. Results showed that 5 and 10 uM concentrations of aflatoxin Bi increased the frequencies of sister chromatid exchange (SCE), micronuclei (MN) and malondialdehyde (MDA) level, whereas superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities decreased. However, when 5 and 10 µg/ml concentrations of LME and RME were added to AFB1, the frequencies of SCE, MN and MDA level decreased but SOD and GPx activities increased. The results of this experiment have clearly shown that LME and RME have strong antioxidative and antigenotoxic effects, and may play a role in the anti-genotoxic activity mechanisms. © by PSP.
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