Full record view
Xu, H.-B./ Yang, T.-H./ Xie, P./ Liu, S.-J./ Liang, Y.-N./ Zhang, Y./ Song, Z.-X./ Tang, Z.-S. 2018[2017]: Pheophytin analogues from the medicinal lichen Usnea diffracta. - Natural Product Research 32(9): 1088-1094. [RLL List # 252 / Rec.# 40031]
Keywords: pheophytin/ Usnea diffracta/ xanthine oxidase
Abstract: A new pheophytin, (132S, 17S, 18S)-132-hydroxy-20-chloro-ethylpheophorbide a (3), along with two known analogues (1-2) were isolated from the lichen Usnea diffracta Vainio (Parmeliaceae). Among them, compound 3 was a rare C-20-chloro type pheophytin obtained from lichens. Their structures were elucidated by extensive spectroscopic analysis, and all the compounds were obtained for the first time from U. diffracta. Compounds (1-3) were evaluated for their xanthine oxidase (XO) inhibitory activities in vitro, and the results showed that 1-3 possessed significant enzyme inhibitory actions with IC50 values of 46.9 ± 3.8, 75.9 ± 7.4 and 42.1 ± 1.7 μg/mL, respectively.
URL: https://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1380019?journalCode=gnpl20
[Email correction]